Reprint of: Virus-Specific T Cells: Broadening Applicability.

TitleReprint of: Virus-Specific T Cells: Broadening Applicability.
Publication TypeJournal Article
Year of Publication2018
AuthorsA Barrett J, Prockop S, Bollard CM
JournalBiol Blood Marrow Transplant
Date Published2018 Mar

Virus infection remains an appreciable cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Although pharmacotherapy and/or antibody therapy may help prevent or treat viral disease, these drugs are expensive, toxic, and often ineffective due to primary or secondary resistance. Further, effective treatments are limited for many infections (eg, adenovirus, BK virus), which are increasingly detected after alternative donor transplants. These deficiencies in conventional therapeutics have increased interest in an immunotherapeutic approach to viral disorders, leading to adoptive transfer of virus-specific cytotoxic T lymphocytes (VSTs), which can rapidly reconstitute antiviral immunity post-transplantation without causing graft-versus-host disease. This review will explore how the VST field has improved outcomes for many patients with life-threatening viral infections after HSCT, and how to broaden applicability beyond the "patient-specific" products, as well as extending to other viral diseases even outside the context of HSCT.

Alternate JournalBiol. Blood Marrow Transplant.
PubMed ID29425515
Grant ListUM1 AI126617 / AI / NIAID NIH HHS / United States